منابع مشابه
Diphosphopyridine nucleotide pyrophosphatase.
Enzymatic splitting of diphosphopyridine nucleotide (DPN)’ by microorganisms, plants, and animal tissues has been known for many years, but the precise nature of this reaction is not well understood (1). Ohlmeyer (2) first observed that adenylic acid (5-phosphoadenosine) appeared when DPN was incubated with yeast maceration juice. Later Heiwinkel (3) identified adenylic acid as a product of the...
متن کاملA reduced pyridine nucleotide pyrophosphatase.
Reaction 1 is catalyzed by DPNase and has been observed in higher animals (1, 2), in Neurospora (3), and in some bacteria (4). Reaction 2 is catalyzed by a deaminase found in Taka-Diastase (5). Reaction 3 is the DPN pyrophosphorylase from hog liver, as described by Kornberg (6) ; it is the only reversible reaction of those shown. The pyrophosphatase splitting shown in Reaction 4 has been observ...
متن کاملSubcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1.
The ectonucleoside pyrophosphatase phosphodiesterase 1 (NPP1/PC-1) is a member of the NPP enzyme family that is critical in regulating mineralization. In certain mineralizing sites of bone and cartilage, membrane-limited vesicles [matrix vesicles (MVs)] provide a sheltered internal environment for nucleation of calcium-containing crystals, including hydroxyapatite. MV formation occurs by buddin...
متن کاملRat liver nucleotide pyrophosphatase/phosphodiesterase is an efficient adenylyl transferase.
Rat liver nucleotide pyrophosphatase/phosphodiesterase I (NPP/PDE) catalysed efficiently the transfer of adenylate from ATP to alcohols (methanol, ethanol, propanol, ethylene glycol, glycerol, 2, 2-dichloroethanol and glycerol 2-phosphate), which acted as adenylate acceptors competing with water with different efficiencies. NPP/PDE kinetics in alcohol/water mixtures were accounted for by rate e...
متن کاملSubstrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors
Nucleotide pyrophosphatase/phosphodiesterase type 1 (NPP1) is a membrane glycoprotein involved in the hydrolysis of extracellular nucleotides. Its major substrate is ATP which is converted to AMP and diphosphate. NPP1 was proposed as a new therapeutic target in brain cancer and immuno-oncology. Several NPP1 inhibitors have been reported to date, most of which were evaluated vs. the artificial s...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1950
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56512-1